According to statistics gathered by GLSEN, the Gay Lesbian Straight Education Network, ten percent of the population is gay, bisexual, or transgender. These students come to school with the needs of any other student. Transgender and gender non-conforming (TGNC) youth are quickly becoming more visible in society. Parents of gender non-conforming children are coming to mental health providers in increasing numbers and are often met with stigma and bias and a lack of education on TGNC health. TGNC youth are turned out of their homes at disproportionate rates and harassed and bullied in school at higher rates than their gender conforming peers. They have higher rates of suicide, depression and substance abuse and face unique medical, legal and social barriers. They also have produced their own cultures and communities to face these challenges. This course will examine the scientific research on TGNC youth in the context of the practical challenges faced by these individuals and their families. This course is imperative as it will enable any counselor or educator to be a reliable source for those youth who feel marginalized due to their sexual orientation or gender identity/expression. This course is appropriate for all K-12 school professionals.